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KMID : 1007520110200030829
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Food Science and Biotechnology
2011 Volume.20 No. 3 p.829 ~ p.833
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Screening of Korean Edible Wild Plants for Estrogenic Activity Using MCF-7 Cell Proliferation Assay
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Lee Young-Min
Jung Ho-Young
Bae Ji-Hyun
Lee Jin-Young
Jang Hwan-Hee
Park Dong-Sik
Kim Jae-Hyun
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Abstract
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This present study was performed to investigate estrogenic activity of Korean edible wild plants for alternative of estrogen replacement therapy in postmenopausal women. When the estrogenic activity was measured by estrogen induced proliferation of MCF-7 cells, of investigated 29 extracts, 3 samples of kudzu vine (Pueraria thunbergiana), Cardamine leucantha, and David Vetchling (Lathyrus davidii) exhibited a significant proliferation of above 20% at concentration of 100 μg/mL. This stimulation of MCF- 7 cell proliferation could be completely blocked by addition of estrogen antagonist ICI 182,780 (100 nM), indicating estrogen receptor-dependent mechanism of these estrogenic effects on MCF-7 cell proliferation.
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KEYWORD
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MCF-7 proliferation assay, estrogenic activity, Korean wild plant
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